With all the hype around machine learning, I occasionally get asked if it could be used to make predictions for particle colliders, like the LHC.

Physicists do use machine learning these days, to be clear. There are tricks and heuristics, ways to quickly classify different particle collisions and speed up computation. But if you’re imagining something that replaces particle physics calculations entirely, or even replace the LHC itself, then you’re misunderstanding what particle physics calculations are for.

Why do physicists try to predict the results of particle collisions? Why not just observe what happens?

Physicists make predictions not in order to know what will happen in advance, but to compare those predictions to experimental results. If the predictions match the experiments, that supports existing theories like the Standard Model. If they don’t, then a new theory might be needed.

Those predictions certainly don’t need to be made by humans: most of the calculations are done by computers anyway. And they don’t need to be perfectly accurate: in particle physics, every calculation is an approximation. But the approximations used in particle physics are controlled approximations. Physicists keep track of what assumptions they make, and how they might go wrong. That’s not something you can typically do in machine learning, where you might train a neural network with millions of parameters. The whole point is to be able to check experiments against a known theory, and we can’t do that if we don’t know whether our calculation actually respects the theory.

That difference, between caring about the result and caring about how you got there, is a useful guide. If you want to predict how a protein folds in order to understand what it does in a cell, then you will find AlphaFold useful. If you want to confirm your theory of how protein folding happens, it will be less useful.

Some industries just want the final result, and can benefit from machine learning. If you want to know what your customers will buy, or which suppliers are cheating you, or whether your warehouse is moldy, then machine learning can be really helpful.

Other industries are trying, like particle physicists, to confirm that a theory is true. If you’re running a clinical trial, you want to be crystal clear about how the trial data turn into statistics. You, and the regulators, care about how you got there, not just about what answer you got. The same can be true for banks: if laws tell you you aren’t allowed to discriminate against certain kinds of customers for loans, you need to use a method where you know what traits you’re actually discriminating against.

So will physicists use machine learning? Yes, and more of it over time. But will they use it to replace normal calculations, or replace the LHC? No, that would be missing the point.